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Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

《医学前沿（英文）》 2009年第3卷第4期页码 491-494 doi: 10.1007/s11684-009-0066-x

摘要： Thl7 cells, a special kind of auxiliary type T cells, can secrete IL-17A, IL-17F, IL-21, IL-22, etc., as a newly discovered T-cell subset in recent years. As a different subset from the Thl and Th2 cells, Th17 cells play an important role in the development of a variety of autoimmune diseases. A current study shows that the IL-6 inflammatory response of the organization in combination with the occurrence of TGF-β can induce the differentiation of Thl7 cells. IL-23 can promote the production of IL17, as well as participate in amplification and maintenance of the survival of IL-l7 generating cells. In this process, STAT3 and ROR-γt are key transcription factors for the growing of Thl7 cells. As our knowledge on Th17 family members is rapidly growing and changing, it will be important to specify their involvement in the induction and regulation of allograft rejection in animal models as well as in clinical settings. Herein, we review the key features of Th17 cells and discuss their potential relevance to transplantation immunity.

关键词： TH17 cells regulation allograft rejection

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Th17 Cells in autoimmune diseases

null

《医学前沿（英文）》 2015年第9卷第1期页码 10-19 doi: 10.1007/s11684-015-0388-9

摘要：

Th17 cells are a new subset of CD4⁺ T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren’s syndrome, inflammatory bowel disease, and multiple sclerosis.

关键词： IL-17 Th17 cells RORγt autoimmune diseases posttranslational modification inhibitors

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Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

《机械工程前沿（英文）》 2016年第11卷第1期页码 3-11 doi: 10.1007/s11465-015-0359-5

摘要：

This study aims to investigate the role played by Xu Guangqi (1562–1633), minister of the Ming Dynasty, in the development of European scientific and technical knowledge in China between the 16th and 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifa (On Western Hydraulics). Several Western books related to machine knowledge are searched to trace the source of the illustrations in Taixi Shuifa. We found that Archimedes’ screw and Ctesibius’ machine, which are included in Vitruvius’ De Architectura volumes, also appear in the work of Xu Guangqi.

关键词： Vitruvius’ De Architectura Xu Guangqi’s Taixi Shuifa Jesuit missionaries Italian Renaissance drawing representation

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17th International Congress of Immunology

会议日期： 2019年10月19日

会议地点：中国/北京/朝阳

主办单位：国际免疫学联合会；中国免疫学会

sources of dissolved organic matter from wastewater treatment plants and their mediation effect on 17α-ethinylestradiol

《环境科学与工程前沿（英文）》 2023年第17卷第6期 doi: 10.1007/s11783-023-1669-1

摘要：

● EE2 photodegradation behavior in the presence of four WWTPs’ DOM was explored.

关键词： Photosensitivity sources 17α-ethinylestradiol Photodegradation Dissolved organic matter Wastewater treatment plants

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The 9th China Engineering Management Forum Guangzhou Consensus

《工程管理前沿（英文）》 2015年第2卷第2期页码 105-107 doi: 10.15302/J-FEM-2015019

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2015 International Summit Forum on Engineering Science and Technology Development Strategy, the 205thChina Engineering Science and Technology Forum, and the 9th China Engineering Management Forum Held

China Engineering Management Forum Organization Committee

《工程管理前沿（英文）》 2015年第2卷第2期页码 195-197 doi: 10.15302/J-FEM-2015032

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Removal of 17β-estradiol in laccase catalyzed treatment processes

XIA Qing,KONG Deyang,LIU Guoqiang,HUANG Qingguo,ALALEWI Aamr,LU Junhe

《环境科学与工程前沿（英文）》 2014年第8卷第3期页码 372-378 doi: 10.1007/s11783-013-0567-3

摘要： The removal of 17β-estradiol (E2) in laccase catalyzed oxidative coupling processes was systematically studied in this work. We focused on the influence of pH and natural organic matter (NOM) on the performance of the enzymatic treatment processes. It was found that the optimal pH for E2 removal was between 4 and 6. The removal of E2 was slightly inhibited in the presence of NOM. Enzymatic transformation of E2 was second-order in kinetics with first-order to both the concentrations of the enzyme and contaminant. Mass spectrum (MS) analysis suggested that coupling products were formed through radical-radical coupling mechanism. The results of this study demonstrated that laccase catalyzed oxidative coupling process could potentially serve as a treatment strategy to control steroid estrogens.

关键词： 17β-estradiol laccase oxidative coupling processes kinetics mechanisms

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Special Issue for the 14th Global Chinese Chemical Engineering Symposium

《化学科学与工程前沿（英文）》 2023年第17卷第10期页码 1321-1322 doi: 10.1007/s11705-023-2351-7

摘要： Special Issue for the 14th Global Chinese Chemical Engineering Symposium

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Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

《化学科学与工程前沿（英文）》 2010年第4卷第2期页码 109-109 doi: 10.1007/s11705-009-0258-6

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利用cyp17a1缺失的伪雄鲤成功构建全雌鲤群体 Article

翟刚, 舒婷婷, 陈贶新, 娄气永, 贾景怡, 黄建飞, 石闯 , 金霞, 贺江燕, 姜冬火, 钱雪桥, 胡炜, 殷战

《工程（英文）》 2022年第8卷第1期页码 181-189 doi: 10.1016/j.eng.2021.03.026

摘要：本研究针对雌鲤生长快于雄鲤的两性生长异形的特性，以cyp17a1 为靶点进行了CRISPR/Cas9介导的基因编辑操作，利用cyp17a1 敲除后形成的伪雄鲤，成功构建了全雌鲤群体首先，我们发现无论遗传性别型为XX还是XY，其cyp17a1 缺失鲤个体性腺均发育为精巢，并能正常产精。其次，利用确定的雄性特异DNA分子标记，筛选到cyp17a1 ^-/- XX伪雄个体，其具有正常的精巢发育和精子发生。将全雌群体和对照组雌雄混合群体各500 尾进行同塘生长对比养殖，至8 月龄或12 月龄时随机抽样检测，发现cyp17a1杂合突变雌鲤体重比同塘性别混养对照组分别高6.60%或32.66%

关键词：鲤两性异形生长 cyp17a1 性类固醇激素全雌群体

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Advances of 12^th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

《化学科学与工程前沿（英文）》 2021年第15卷第3期页码 461-463 doi: 10.1007/s11705-020-2026-6

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The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

《农业科学与工程前沿（英文）》 2016年第3卷第2期页码 147-152 doi: 10.15302/J-FASE-2016099

摘要： In cows, progesterone (P4) is essential for the maintenance of pregnancy and successful embryo development is dependent on the maternal immunomodulation of Th-related cytokines. However, investigation of the relationship between P4 and Th immunity in cattle remains incomplete. Therefore, we evaluated plasma P4 concentrations and expressions of three Th-related cytokines, interleukins IL-1β, IL-4 and IL-6, in 15 pregnant and 11 non-pregnant cows 0, 14, 18, 21, and 28 d post artificial insemination. Pregnant cows had significantly higher plasma P4 levels and pregnant cows with higher P4 on 14 d tended to have higher P4 in the subsequent period of pregnancy. There was no difference in IL-4 and IL-6 expression between pregnant cows and non-pregnant cows, whereas plasma IL-1β was temporally upregulated on 21 d. The cytokines measured were not affected in either the high-P4 group (>11.1 ng·mL ) or the low-P4 group (<11.1 ng·mL ) in pregnant cows. A weak negative correlation between IL-1β and IL-6 was observed, but none of the cytokines was associated with a change in plasma P4. In conclusion, there was no clear relationship between P4 and Th immunity in maternal plasma in the pregnant cows, which differs from what occurs in humans and mice during early pregnancy.

关键词： dairy cow progesterone pregnancy cytokine

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Rolling-element bearings in China: From ancient times to the 20th century

Lie SUN,Ang LI

《机械工程前沿（英文）》 2016年第11卷第1期页码 33-43 doi: 10.1007/s11465-016-0373-2

摘要：

The development of rolling-element bearings in China has spanned a long period. Based on several typical and important cases, the present article reconstructs the history of rolling-element bearings in China by dividing it into four stages according to the various characteristics of the bearings. The first stage represents the origin of rolling bearings in China, which remains controversial because of several suspected races and cages that were likely the components of bearings more than a millennium ago. At the second stage, a type of simple roller bearing was used for astronomical instruments not later than the 13th century based on clear philological and physical evidence. A similar bearing was also applied to an abridged armillary in the 17th century. Another type of spherical thrust bearings with rolling elements, which is a key component of a traditional Chinese windmill, could support a rotating shaft that moves rotationally and at an angle. At the third stage, the Chinese began studying and using the so-called European-style bearing since the 17th century. Moreover, over the last 100 years, the modern rolling bearing industry was gradually established in China, particularly because of the technology transfer from the Soviet Union in the 1950s. At the fourth stage, the Chinese government initiated the relatively rapid development of bearing technology. The government launched the “bearing movement” from the 1950s to the 1960s to establish the modern bearing industry and to promote rolling bearings as replacement for traditional sliding bearings. Furthermore, a number of large professional factories and institutions in China have continually introduced advanced technology and equipment. At present, these companies and institutions play a significant role in the international bearing industry.

关键词： bearing movement rolling-element bearing China early rolling bearings technology transfer

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养殖业“十三五”发展趋势与政策建议

“养殖业十三五规划战略研究”项目组

《中国工程科学》 2016年第18卷第1期页码 17-21 doi: 10.15302/J-SSCAE-2016.01.003

摘要：

“十三五”期间乃至未来一段时间内，我国养殖产品需求仍呈刚性增长，但是养殖业面临资源短缺日趋严重、环境制约日益加剧等不利局面，同时面临国际竞争对国内产业冲击加剧等新的形势，未来我国养殖业必须走可持续发展道路。本文基于对我国养殖业的发展现状、可持续发展所面临的挑战，形成对我国养殖业可持续发展形势的基本判断，针对“十三五”，凝练了养殖业可持续发展的战略目标、基本原则和战略重点，并提出了“进一步明确养殖业在现代农业中的战略主导地位”“合理利用国际市场保障我国食物安全”“加快启动和实施一批养殖科技重点研发计划”等重大建议，为我国养殖业加快发展方式转变、实现现代化提供理论支撑。

关键词：养殖业可持续发展十三五趋势分析食物安全